A new combination of drugs that could be helpful in treating lip herpes more effectively has been developed by a team of researchers at the University of Kent.
The study, published in Frontiers in Microbiology, explains how researchers tested different drugs by applying them to various cell cultures and discovered how some drugs used for heartburn improve the effectiveness of antiviral acyclovir. The latter is the drug used to fight the Herpes simplex virus.
The drugs used by researchers in combination with acyclovir are drugs treated for heartburn and are included in the category of proton pump inhibitors. They also include omeprazole.
Herpes simplex can be very worrying for people with weak or suppressed immune systems. In these people it can cause life-threatening conditions or even blindness as the infected person can transfer the virus from the lips to other parts of the body including the eyes (a process also called self-inoculation). It can lead to conjunctivitis or keratitis in the eyes and this can worsen, especially if the patient continues to rub the eye at the point of injury.
The drugs to treat heartburn were combined by researchers, led by Professor Martin Michaelis of the School of Biosciences, with acyclovir on cell cultures. The researchers found that they reduced the spread of the aforementioned virus in cells and the maximum effect was caused by omeprazole.
“The combination of these two drugs could significantly improve the broader treatment of the herpes simplex virus,” says Martin Michaelis of the University of Kent.
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